Dermatologists struggle to accurately differentiate between visually similar skin conditions (psoriasis, parapsoriasis, cutaneous lymphoma) without invasive biopsies

Dermatologists face diagnostic uncertainty when distinguishing between psoriasis, parapsoriasis, and early-stage cutaneous lymphoma, which present with overlapping clinical features. Current diagnostic methods rely heavily on skin biopsies, which are invasive, time-consuming, and create patient anxiety. Misdiagnosis leads to incorrect treatment, disease progression, and delayed cancer detection in lymphoma cases.